Changes in the structural organization of lymph nodes during short-term exposure to monosodium glutamate

Monosodium glutamate is a common food additive that belongs to the group of flavor enhancers used in wide range products. The potentially negative impact monosodium on human health prompts us question safety its widespread use. article presents and analyzes data an experimental study conducted 40 white male female rats reproductive age (2.5-3.5 months old) weighing 120-190 g. purpose histological, morphometric, ultrastructural changes lymph nodes under conditions short-term exposure glutamate. An animals (10 rats, 10 rats), which was standard vivarium diet, given at dose 0.07 g/kg rat body weight by pipette every day same time for four weeks, followed free access water food. In intact group, structure mesenteric corresponded species norm. animals, after weeks exposure, it found paracortical area contained g larger number post-capillary venules with high endothelium compared control groups animals. Changes vascular bed were established, particular, arteries both thickness organ hilum contain thickened wall, their lumen full blood. Veins are also full-blooded, dilated deformed. Swelling parenchyma signs immune activity observed. There significant decrease relative lymphoid nodules mantle zone, increase medullary substance node, corticomedullary index, germinal centers, area, cords. Part lymphocytes all populations apoptosis. other part has uneven karyolemma contour, nucleolus not visualized lymphocytes, cytoplasm clear contains organelles. Mitochondria hypertrophied light matrix. Therefore, even daily glutamate, namely causes structural organization nodes.